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Anti-Bet v 1 mAbs

简要描述:

This antibody reacts with native Bet v 1 and homologous allergens. This antibody can also bind Bet v 1‐related allergens namely Aln g 1, Cor a 1, Mal d 1. This antibody specifically binds C‐terminal F2 domain of Bet v 1 (amino acids 130‐160) and the binding epitope comprises the amino acid sequence ‘KAEQVKASKEMGETLLRAVESYLLAHSDAYN‘. This antibody recognized not only folded Bet v 1 but also a synthetic, unfolded peptide derived from the C‐terminus of Bet v 1.

产品参数:

Cat. No.:MABL-3386

Species:Engineer

Species Reactivity:Alnus glutinosa (European alder), Betula alnus var. glutinosa, Betula pendula (European white birch), Betula verrucosa, Corylus avellana (European hazel), Corylus maxima, Malus domestica (Apple), Pyrus malus

Type:Recombinate

Application:ELISA

详细介绍

Key features and   details


Cat. No.

MABL-3386

Name

Anti-Bet v 1  mAbs

Clone No.

AFD-H3-1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ELISA

Species Reactivity

Alnus glutinosa (European alder), Betula   alnus var. glutinosa, Betula pendula (European white birch), Betula   verrucosa, Corylus avellana (European hazel), Corylus maxima, Malus domestica   (Apple), Pyrus malus

Basic Information


Specificity

This antibody reacts with native Bet v 1 and   homologous allergens. This antibody can also bind Bet v 1‐related allergens   namely Aln g 1, Cor a 1, Mal d 1. This antibody specifically binds C‐terminal   F2 domain of Bet v 1 (amino acids 130‐160) and the binding epitope comprises the amino acid sequence 'KAEQVKASKEMGETLLRAVESYLLAHSDAYN'. This antibody recognized not only folded Bet v 1 but also a synthetic, unfolded peptide   derived from the C‐terminus of Bet v 1.

Alternative Name

BETVIA; BETVI; Major pollen allergen Bet v   1-A; Allergen Bet v 1-A; ALNGI; Major pollen allergen Aln g 1; Allergen Aln g   I; CORAI; Major pollen allergen Cor a 1; Allergen Cor a I; MALDI; MALD1;   Major allergen Mal d 1

UniProt

P15494; P38948; Q08407; Q9SYW3

Immunogen

The original antibody was isolated from a phage‐displayed combinatorial single‐chain fragment (ScFv) library generated from the peripheral blood mononuclear cells of an immunized subject and screened for Bet v 1‐reactive antibody fragments.

Application Notes

The reactivity of this   antibody to Bet v 1 and related allergens Aln g 1, Cor a 1, Mal d 1 was   determined using ELISA. This antibody reacted best with rBet v 1 but also   with the cross‐reactive allergens from alder (Aln g 1), hazel (Cor a 1), and apple (Mal d 1). The original scFv version of this antibody binds Bet v 1,   Aln g 1, Cor a 1, and Mal d 1 with a binding affinity of Bet v 1: KD= 6.22 ×   10−10 M, Mal d 1: KD= 2.57 × 10−9 M, Aln g 1: KD= 2.96 × 10−9 M and Cor a 1:   KD= 6.83 × 10−9 M respectively (PMID:29315611). This antibody inhibited   allergic patients’ polyclonal IgE binding to Bet v 1, and partially   suppressed allergen‐induced basophil activation (PMID: 29315611).

Antibody First   Published

Gadermaier et al. Isolation of a   high‐affinity Bet v 1‐specific IgG‐derived ScFv from a subject vaccinated   with hypoallergenic Bet v 1 fragments. Allergy. 2018 Jul; 73(7): 1425–1435. PMID:29315611

Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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