Cat. No.
MABL-191
Application
WB, ELISA, IF, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
GC92
From
Recombinant Antibody
Specificity
This antibody is specific for gephyrin. Gephyrin is a microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). It acts as a major instructive molecule at inhibitory synapsees, where it also clusters GABA type A receptors.
Alternative Names
GPHN; Molybdopterin adenylyltransferase; MPT adenylyltransferase; Domain G; Molybdopterin molybdenumtransferase; MPT Mo-transferase; Domain E
UniProt
Q9NQX3
Immunogen
This antibody was generated against the gephyrin antigen.
Application Notes
This antibody is recommended for detection and analysis of Gephyrin by ELISA, immunofluorescence, immunohistochemistry and western blot.
Antibody First Published
Andrews et al. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain eLife. 2019; 8: e43322. PMID:30667360
Note on publication
Describes the generation of a library of recombinant monoclonal antibodies (R- mAbs) from a pool of mAb-producing hybridomas for neuroscience research.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
