Key features and details | |
Cat. No. | MABL-3394 |
Name | Anti-IL-1B mAbs |
Clone No. | AFD-IC8 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | neutralize |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human Interleukin-1 beta, which is a potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. It promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. It also plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. |
Alternative Name | IL1B; IL-1β; 1L1F2; Interleukin-1 beta; IL-1 beta; Catabolin; 1C8 |
UniProt | P01584 |
Immunogen | The original mouse antibody was generated by immunizing mice with human IL-1B protein. The humanized version was generated by grafting CDRs of the original mouse antibody onto human framework regions. |
Application Notes | This antibody is the humanized version of original mouse antibody IC8. This antibody binds human IL-1B with a binding affinity of Kd= 0.28 nM. The Fab version of this antibody was reported to neutralize IL-1B activity both in an in vitro and an in vivo assay (US7608694). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
