Anti-Sodium-dependent noradrenaline transporter mAbs [2-3B2](MABL-222)

MABL-222

ICC, IP, WB, IF, IHC

Engineer antibody

Rat, Mouse

2-3B2

Recombinant Antibody

This antibody is specific for the sodium-dependent noradrenaline transporter. This antibody is an amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Slc6a2; Norepinephrine transporter; NET; Solute carrier family 6 member 2

O55192

This antigen was raised by immunizing a BALB/c mouse with the sodium-dependent noradrenaline transporter antigen.

Striatum tissues from 2- and 8-month-old wild-type and transgenic mice were immunoblotted using this antibody (Graham and Sidhu, 2010; pmid:20077428). Freshly dissected mouse brain tissues were immunoblotted using this antibody (Ye et al, 2015; pmid:26793096). This antibody was usaed for immunoblotting on protein from the mesenteric PVAT, mesenteric resistance vessels, adipocytes, SVF, and vena cava. The test animal used was a rat (Ayala-Lopez et al, 2015; pmid:26432838). ). Mouse NET protein was immunoprecipitated using this antibody (Mannangatti et al, 2015; pmid:25724654). Mouse NET protein was immunoblotted using this antibody (Mannangatti et al, 2015; pmid:25724654). Immunoblot was preformed on proteins from NET knockout mice using this antibody (Fentress et al, 2013; pmid:24102798). Alvarial osteoblasts isolated from 3–4-day-old neonatal mice were immunoblotted using this antibody (Ma et al, 2013; pmid:24005671). Immunocytochemistry was performed in formalin-fixed long bones of neonatal mice using this antibody (Ma et al, 2013; pmid:24005671). brain tissue from mice homozygous for a mutant human A53T-α-Syn transgene driven by the prion promoter (A53T) were immunoblotted with this antibody (Oaks et al, 2013; pmid:23560093).Proteins from knock-in mice carrying the NET A457P allele were imunnoblotted with this antibody (Shirley-Rice et al, 2013; pmid:23580201). In a study investigating the role of the sodiumdependent vitamin C transporter-2 (SVCT2) in transporting VC at the cortical nerve terminal. This antibody was used for immunostaining on cultured SCG neurons (Pierce et al, 2015; pmid:26366722).

Graham and Sidhu. Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior J Neurosci Res. 2010 Jun;88(8):1777-83. PMID:20077428

The effect of the hA53T mutation during development was examined by analyzing the protein expression of norepinephrine (NET), serotonin (SERT), and dopamine (DAT) transporters in addition to assessing locomotor and anxiety-like behavior.

100 μg Purified antibody.

1 mg/ml.

Protein A affinity purified

PBS with 0.02% Proclin 300.

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.