Cat. No.
MABL-3884
Application
fusion, IP, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
FWP51
From
Recombinant Antibody
Specificity
FWP51 binds to the extracellular domain of c-erbB-2.
Alternative Names
CD340; Receptor tyrosine-protein kinase erbB-2; Neu; HER2; MLN19; Metastatic lymph node gene 19 protein; p185erbB2
UniProt
P04626
Immunogen
HOUA-1 cells from endometrial cancer.
Application Notes
The antibody binds specifically to CA125, membrane associated glycoprotein which acts as a biomarker for ovarian cancer detection, and is also associated with endometrial, fallopian tube, lung, breast and gastrointestinal tract cancers. CA125 plays an important role in tumorigenesis by enhancing the metastasis of tumour cells, increasing immune system evasion, inducing motility and resistance to chemotherapy. The monoclonal antibody 196-14 can be used for both in vivo and in vitro applications, and potentially in the diagnosis and treatment of endometrial or ovarian cancers expressing high levels of CA125.
Antibody First Published
Saga T, Ishiwata I, Endo K, Sakahara H, Koizumi M, Watanabe Y, Nakai T, Hosono M, Ishikawa H, Sawada M. An antibody-tumor model for the targeting of CA125-producing gynecologic malignancies. Jpn J Cancer Res. 1990 Nov;81(11):1141-8. PMID:2125039
Note on publication
Describes the generation of two monoclonal antibodies reactive against the ovarian cancer-associated antigen CA125.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
