Cat. No.
MABL-209
Application
ICC
Isotype
Engineer antibody
Species Reactivity
Rat, Human, Mouse
Clone No.
L8/15R
From
Recombinant Antibody
Specificity
This antibody is specific for Snapin. Snapin is a component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Alternative Names
SNARE-associated protein Snapin; SNAPIN; Biogenesis of lysosome- related organelles complex 1 subunit 7; BLOC-1 subunit 7; Synaptosomal-associated protein 25-binding protein; SNAP-associated protein; L8/15
UniProt
O95295
Immunogen
This antibody was raised against a synthetic peptide of amino acids 115-136 of human snapin.
Application Notes
Immunocytochemistry was preformed on neurones or mouse N11 cells cultured on poly-L-lysinecoated coverslips with this antibody (Makani et al, 2013; PMID:24118254).
Antibody First Published
Makani et al. Annexin A1 complex mediates oxytocin vesicle transport J Neuroendocrinol. 2013 Dec;25(12):1241-1254. PMID:24118254
Note on publication
A new molecular complex consisting of annexin A1 (ANXA1) was discovered, A- kinase anchor protein 150 (AKAP150) and microtubule motor that controls the distribution of oxytocin vesicles between the axon and the cell body in a protein kinase A (PKA)- and protein kinase C (PKC)- sensitive manner.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
