Cat. No.
MABL-240
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
F28C4
From
Recombinant Antibody
Specificity
This antibody binds human myelin basic protein (MBP), acetyl residues 1-9 (ASQKRPSQR). The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis.
Alternative Names
MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein
UniProt
P02686
Immunogen
The original antibody was generated by immunizing PL/J mice with MBP acetyl residues 1-9.
Application Notes
This antibody shares a cross reactive idiotpe with the TCRs, possibly as a result of having similar fine epitope specificity and sequence homology (PMID: 7517973). This antibody can be used for the detection of MBP in a solution using ELISA (PMID: 8567971).
Antibody First Published
Maier et al. A V lambda x-bearing monoclonal antibody with similar specificity and sequence to encephalitogenic T cell receptors. J Immunol. 1994 Aug 1;153(3):1132-40. PMID:7517973
Note on publication
Describes the generation of this antibody and compares its sequences homology to encephalitogenic T cell receptors.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
