Cat. No.
MABL-241
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
F23C6
From
Recombinant Antibody
Specificity
This antibody binds human myelin basic protein (MBP), acetyl residues 1-9 (ASQKRPSQR). The MBP isoforms 4 and 14 along with PLP are most abundant protein components of the myelin membrane in the CNS. The smaller isoforms are believed to have an important role in remyelination of denuded axons in multiple sclerosis.
Alternative Names
MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein; F23
UniProt
P02686
Immunogen
The original antibody was generated by hyperimmunization of BALB/c mice with a synthetic peptide comprising human MBP acetyl residues 1-9.
Application Notes
This antibody can be used for the detection of human MBP in a sample using ELISA. This antibody was found to react with human MBP peptides like acetyl 1-9, 1-14, and 1-44 (PMID: 1698857).
Antibody First Published
Zhou et al. An idiotype shared by monoclonal antibodies to different peptides of human myelin basic protein. J Immunol. 1990 Oct 15;145(8):2554-60. PMID:1698857
Note on publication
Describes the generation of antibody against human myelin basic protein and describes use of complementary peptide to human MBP peptide 1-9 to raise murine mAb with anti-Id activity.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
