Cat. No.
MABL-3729
Application
Activate, FC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
LOB12.3
From
Recombinant Antibody
Specificity
This antibody binds to mouse 4-1BB (CD137).
Alternative Names
CD137; TNFRSF9; 41BB; 4-1BBL Ligand; Tumor necrosis factor superfamily member 9; TNF receptor superfamily member 9; LOB 12.3; LOB123; LOB12.3
UniProt
P20334
Immunogen
This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
Application Notes
This antibody can be used to detect mouse 4-1BB (CD137). In its original rat IgG1 format, this antibody had agonistic effect and prolonged survival of mice bearing CT26 or A31 tumors. In the original publication another clone LOB12 disclosed which has a rat IgG2a isotype. This has led to some confusion in the literature with regards to the original isotype of LOB12 and LOB12.3. We offer this antibody in both formats as well as murine versions so that researchers may choose the isotype most appropriate for their assays.
Antibody First Published
Taraban Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol. 2002 Dec;32(12):3617-27 PMID:12516549
Note on publication
Describes the generation of this antibody and initial characterisation of its agonistic properties.
Size
210 μg Purified antibody.
Concentration
111 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 410.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 130⁰C.
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