Cat. No.
MABL-5964
Type
Mouse anti-Estrogen Receptor Alpha (human and mouse).
Clone No
LSERASC1.
Shipped
Shipped with Ice Packs
Description
Estrogen Receptor Alpha, Mouse Anti Human
Synonyms
ER-alpha
Introduction
Estrogen receptors α (ERα, ER; NR3A1) is a member of the steroid hormone receptor family. ERα is a ligand-activated transcription factor. ERα contain DNA binding and ligand binding domains. ERα is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. The natural ligand for ER is 17β-estradiol, the classical estrogenic compound. The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes.
Physical Appearance
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Immunogen
Recombinant human ER-alpha.
Ig Subclass
Mouse IgG.
Purification Method
Protein A.
Formulation
1mg/ml in PBS (after reconstitution).
Storage Procedures
Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
Stability / Shelf Life
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Applications
Western Blot, Immunofluorescent Staining, Immunohistochemistry, flow cytometry, immunoprecipitation.
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipping Conditions
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Solubility
Reconstitute with of H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Titer
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