Key features and details | |
Cat. No. | MABL-3408 |
Name | Anti-ST2 mAbs |
Clone No. | AFD-C11 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds soluble form of human ST2 which is a member of the interleukin (IL)-1 receptor family. IL-33 is the ligand for ST2, which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues. In in vitro and in vivo models, ST2L transduces the effects of IL-33, while excess sST2 or abnormalities in ST2 signaling leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. Circulating soluble ST2 concentration is believed to reflect cardiovascular stress and fibrosis. ST2 is a new cardiovascular biomarker for assessing acute heart failure and predicting the outcome of chronic heart failure. |
Alternative Name | ST2; IL1RL1; IL-1RL1; DER4; T1; IL-33Rα; Interleukin-1 receptor-like 1; Protein ST2; Growth Stimulation Expressed Gene 2; suppression of tumorigenicity 2 |
UniProt | Q01638 |
Immunogen | The original antibody was generated by immunizing BALB/c mice with human ST2 protein. |
Application Notes | The original IgG antibody binds human ST2 recombinant protein with a binding affinity of Kd= 0.5 X 10^(-10)M. This antibody was used as a capture antibody in combination with HRP labelled D12 as detection antibody for the development of a double-antibody sandwich ELISA for detection of soluble ST2 in blood samples (CN117024595). |
Antibody First Published | |
Note on publication | Describes the generation and characterization of antibodies against Domain I and III of human ST2L. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
