Cat. No.
MABL-3869
Application
IP, WB, ELISA, FC, IF, IHC-Fr
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
TA99
From
Recombinant Antibody
Specificity
Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.
Alternative Names
Melanoma antigen gp75; 5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; Catalase B; Glycoprotein 75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
UniProt
P17643
Immunogen
70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.
Application Notes
This antibody binds to human and murine TRP-1 and had been under evaluation for the treatment of tumours.
Antibody First Published
Welt S, Mattes MJ, Grando R, Thomson TM, Leonard RW, Zanzonico PB, Bigler RE, Yeh S, Oettgen HF, Old LJ. Monoclonal antibody to an intracellular antigen images human melanoma transplants in nu/nu mice. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4200-4. PMID:3473501
Note on publication
Describes the isolation of TA99 from mice immunized with the pigmented melanoma cell line SK-MEL-23 and the characterisation by radioimmunolocalisation showing the tumor imaging.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
