Cat. No.
MABL-3766
Application
ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
196-14
From
Recombinant Antibody
Specificity
The antibody binds to CA125 with a Kd of 0.83 nM reported for the original antibody.
Alternative Names
MUC16; Cancer antigen 125; carcinoma antigen 125; carbohydrate antigen 125; mucin 16
UniProt
Q8WXI7
Immunogen
HOUA-1 cells from endometrial cancer.
Application Notes
The antibody binds specifically to CA125, membrane associated glycoprotein which acts as a biomarker for ovarian cancer detection, and is also associated with endometrial, fallopian tube, lung, breast and gastrointestinal tract cancers. CA125 plays an important role in tumorigenesis by enhancing the metastasis of tumour cells, increasing immune system evasion, inducing motility and resistance to chemotherapy. The monoclonal antibody 196-14 can be used for both in vivo and in vitro applications, and potentially in the diagnosis and treatment of endometrial or ovarian cancers expressing high levels of CA125.
Antibody First Published
Saga T, Ishiwata I, Endo K, Sakahara H, Koizumi M, Watanabe Y, Nakai T, Hosono M, Ishikawa H, Sawada M. An antibody-tumor model for the targeting of CA125-producing gynecologic malignancies. Jpn J Cancer Res. 1990 Nov;81(11):1141-8. PMID:2125039
Note on publication
Describes the generation of two monoclonal antibodies reactive against the ovarian cancer-associated antigen CA125.
Size
247 μg Purified antibody.
Concentration
148 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 447.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 167⁰C.
![Anti-VEGF [Bevacizumab] (MABL-](/public/static/common/images/not_adv.jpg)
