Cat. No.
MABL-3805
Application
functional assay, inhibit, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
MBM-12
From
Recombinant Antibody
Specificity
This antibody binds the human growth/differentiation factor 15 (GDF-15) also known as macrophage inhibitory cytokine 1. GDF-15 is a divergent member of the transforming growth factor-β (TGF- β) superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF- 15 is abundant in placenta. It regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 is widely explored as a biomarker for disease prognosis.
Alternative Names
MIC-1; GDF-15 MIC1; PDF; PLAB; PTGFB; NAG-1; NRG-1; NAG1; NRG1;Growth/differentiation factor 15; growth and differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
UniProt
Q99988
Immunogen
This antibody was isolated from a human single chain Fv (scFv) phage library using phage display technology. The library was generated from the mRNA obtained from the spleen of an immunized mouse injected with recombinant human GDF-15 protein.
Application Notes
The binding characterization of this antibody was done using ELISA. This antibody was reported to inhibit tube formation of HUVEC cells and branching of arterial sections. This antibody can effectively block the angiogenesis-inducing function of MIC-1 (KR101346181).
Antibody First Published
Note on publication
Size
286 μg Purified antibody.
Concentration
187 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 486.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 206⁰C.
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