Cat. No.
MABL-3811
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
SER4
From
Recombinant Antibody
Specificity
The antibody binds specifically to the extracellular domain of human ErbB-2.
Alternative Names
ERBB2; Receptor tyrosine-protein kinase erbB-2; human epidermal growth factor receptor 2;
UniProt
P04626
Immunogen
Recombinant HER2/neu.
Application Notes
The antibody binds to human ErbB-2, a receptor tyrosine kinase (RTK) controlling cell growth and microtubule stabilization. Full-length antibody or Fab fragments cross-linked by secondary antibody had a growth-inhibiting effect onf ErbB-2 positive MDA-MB-453 cells. This effect was not seen with Fab fragments alone.
Antibody First Published
Itoh et al. Molecular structural and functional characterization of tumor suppressive anti-erbB-2 monoclonal antibody by phage display system. Journal of Biochemistry 2003; 133(2):239-245 PMID:12761188
Note on publication
Describes the generation of the SER4-monoclonal antibody and how the antibody inhibits cell growth in vitro.
Size
292 μg Purified antibody.
Concentration
193 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 492.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 212⁰C.
![Anti-VEGF [Bevacizumab] (MABL-](/public/static/common/images/not_adv.jpg)
