Cat. No.
MABL-3854
Application
WB, ELISA
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
237mAb
From
Recombinant Antibody
Specificity
The antibody binds specifically to the Tn antigen with a Kd of 140 nM.
Alternative Names
N-acetylgalactosamine-T/S; O-linked N-acetylgalactosamine on a threonine or serine residue
UniProt
Immunogen
The glyco-dodecapeptide ERGT(GalNAc)KPPLEELS.
Application Notes
The antibody binds to serine- and threonine linked O-linked N-acetylgalactosamine, a posttranslational glycosylation that is highly characterisitic for Ag104A, an aggressive fibrosarcoma.
Antibody First Published
Schietinger et al. A mutant chaperone converts a wild-type protein into a tumor-specific antigen. Science 2006; 314:304-308 PMID:17038624
Note on publication
Describes how a wild-type transmembrane protein can be transformed into a tumor- specific antigen and how this epitode can be used to generate a specific monoclonal antibody with antitumor activity.
Size
335 μg Purified antibody.
Concentration
236 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 535.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 255⁰C.
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