Cat. No.
MABL-3855
Application
confocal microscopy, immunogen, in vivo, Block, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
scFv40
From
Recombinant Antibody
Specificity
This antibody recognizes the idiotype of trastuzumab, mimicking HER2 epitopes.
Alternative Names
human HER2 mimetic
UniProt
Immunogen
Trastuzumab F(ab')2 fragments.
Application Notes
This antibody binds to the idiotype of trastuzumab, effectively mimicking HER2 epitopes. In a murine in vivo model, it elicited anti-HER2 antibodies, offering protection against HER2- positive SK-OV-3 tumor cells (Ladjemi et al., 2011; PMID: 21294885). Additionally, specialized trastuzumab- fused masked forms of this antibody—T-scFv40 + TEV, T-scFv40 + Factor Xa, and T-scFv40 + TEV + Factor Xa—were used to evaluate binding affinity to HER2 via flow cytometry and confocal microscopy (Orozco et al., 2022; PMID: 35799328).
Antibody First Published
Ladjemi et al. Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice. Breast Cancer Res. 2011 Feb 4;13(1):R17. PMID:21294885
Note on publication
Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice.
Size
336 μg Purified antibody.
Concentration
237 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 536.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 256⁰C.
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