Cat. No.
MABL-3856
Application
immunogen, Block
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
scFv69
From
Recombinant Antibody
Specificity
This antibody recognises the idiotype of trastuzumab, mimicking HER2 epitopes.
Alternative Names
human HER2 mimetic
UniProt
Immunogen
Trastuzumab F(ab')2 fragments.
Application Notes
This antibody binds to the idiotype of trastuzumab mimicking HER2 epitopes. In a murine in vivo model this antibody was able to ellicit anti-HER2 antibodies which protected against HER2- positive SK-OV-3 tumour cells.
Antibody First Published
Ladjemi et al. Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice. Breast Cancer Res. 2011 Feb 4;13(1):R17. PMID:21294885
Note on publication
Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice.
Size
337 μg Purified antibody.
Concentration
238 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 537.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 257⁰C.
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