Key features and details | |
Cat. No. | MABL-010 |
Name | Anti-Prion Protein mAbs |
Clone No. | AFD-31C6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | Binds human PrP residues 143-149. |
Alternative Name | PrP; ASCR; CD-Antigen |
UniProt | P04156 |
Immunogen | Recombinant mouse scrapie-Prion protein residues 23-231 (rMoPrP23-231). |
Application Notes | This is antibody recognises and binds to residues 143-149 of PrP. High Levels of PrP (Prion Protein) are found in the brain of humans and animals that are infected with transmissible spongiform encephalopathies such as Creutzfeld-Jakob disease (CJD), Gerstmann-Straussler disease in humans or bovine spongiform encephalopathy (BSE) in cattle. |
Antibody First Published | Kim et al. 2004 Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies. Virology. 2004; 320(1):40-51 PMID:15003861 |
Note on publication | Describes the generation of several monoclonal antibodies against PrP by immunising PrP gene-ablated mice with the pathogenic form of PrP |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
