Key features and details | |
Cat. No. | MABL-012 |
Name | Anti-Alpha-Synuclein mAbs |
Clone No. | AFD-NAC32 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, Block, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | Binds the nonamyloid component of alpha-Synuclein. |
Alternative Name | SNCA |
UniProt | P37840 |
Immunogen | Biotin-labeled peptide spanning amino acids 53-87 of alpha-synuclein. |
Application Notes | This is a synthetic IgG binding to alpha-Synuclein which is involved in the regulation of dopamine release and transport. It induces fibrillisation of the tau-protein and reduces the neuronal responsiveness to several apoptotic signals. Involved in the pathogenesis of Parkinson disease. |
Antibody First Published | Lynch et al. 2008 An scFv Intrabody against the Nonamyloid component of alpha-Synuclein Reduces Intracellular Aggregation and Toxicity Journal of Molecular Biology 2008; 377:136- 147 PMID:18237741 |
Note on publication | Describes the generation of an scFv intrabody against the non-amyloid component of alpha-Synulcein and demonstrates its effect in counteracting mutant synuclein aggregation. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
