Anti-Neurotoxin AahII mAbs

Cat. No.

MABL-017

Name

Anti-Neurotoxin AahII mAbs

Clone No.

AFD-4C1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

 NTRL, ELISA

Species Reactivity

 Androctonus australis hector

Basic Information

Specificity

 This scFv binds specifically to the   C-terminal region of the toxin.

Alternative Name

 neurotoxin II; alpha-mammal toxin II

UniProt

 P01484

Immunogen

 C-terminus of AahII

Application Notes

 This scFv binds to the C-terminus of the   neurotoxin AahII, which binds and blocks sodium channels in a   voltage-independent manner. The antibody neutralizes the toxin.

Antibody First Published

Mousli et al. 1999 A recombinant single-chain   antibody fragment that neutralizes toxin II from the venom of the scorpion   Androctonus australis hector. FEBS Letters 1999; 442(2- 3):183-188   PMID:9928998

Note on publication

 Describes the engineering of an scFv that,   similar to the whole antibody, neutralizes the activity of the neurotoxin.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.