Key features and details | |
Cat. No. | MABL-033 |
Name | Anti-Galanin mAbs |
Clone No. | AFD-4B3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ICC, WB, Block, ELISA |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody. |
Alternative Name | Gal peptide |
UniProt | P22466 |
Immunogen | C-terminal fusions of KLH to human galanin, |
Application Notes | The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
