Key features and details | |
Cat. No. | MABL-672 |
Name | Anti-CD106 mAbs |
Clone No. | AFD- B-K9 (C106-K9) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | B-K9 antibody recognizes CD106 (VCAM1). CD106 is a member of the Ig superfamily. It is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. |
Alternative Name | VCAM1; Vascular cell adhesion protein 1; V-CAM 1; INCAM-100 |
UniProt | P19320 |
Immunogen | This antibody was raised by immunizing Balb/c mice against activated human umbilical vein endothelial cells (HUVEC). |
Application Notes | B-K9 antibody inhibits the binding of leukocytes to VCAM-1 on stimulated endothelial cells, and thus it blocks the ability of white blood cells to attach themselves to the activated epithelium during, for instance, inflammation. Consequently, this antibody might be used in research where leukocytes adhesion-blocking is required (Uotila et al., 2014; Wagner et al. 2011). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
