Anti-CD106 mAbs

Cat. No.

MABL-672

Name

Anti-CD106 mAbs

Clone No.

AFD- B-K9 (C106-K9)

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, FC

Species Reactivity

Human

Basic Information

Specificity

B-K9 antibody recognizes CD106 (VCAM1).   CD106 is a member of the Ig superfamily. It is a cell surface   sialoglycoprotein expressed by cytokine-activated endothelium. This type I   membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction,   and may play a role in the development of artherosclerosis and rheumatoid   arthritis.

Alternative Name

VCAM1; Vascular cell adhesion protein 1;   V-CAM 1; INCAM-100

UniProt

P19320

Immunogen

This antibody was raised by immunizing Balb/c mice against activated human umbilical vein endothelial cells (HUVEC).

Application Notes

B-K9 antibody inhibits the binding of   leukocytes to VCAM-1 on stimulated endothelial cells, and thus it blocks the   ability of white blood cells to attach themselves to the activated epithelium   during, for instance, inflammation. Consequently, this antibody might be used   in research where leukocytes adhesion-blocking is required (Uotila et al., 2014; Wagner et al. 2011).

Antibody First Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.