Key features and details | |
Cat. No. | MABL-973 |
Name | Anti-CD44 mAbs |
Clone No. | AFD- YKIX 337.8.7 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FACS, IP, IF, IHC |
Species Reactivity | Dog, Raccoon |
Basic Information | |
Specificity | YKIX 337.8.7 specifically binds to CD44. CD44 has high affinity for hyaluronic acid (HA) and can mediate cell-cell and cell-matrix interactions through its affinity for HA (and possibly also osteopontin, collagens, and matrix metalloproteinases (MMPs)). Adhesion with HA is important for cell migration, tumor growth and progression. CD44 also plays a role in lymphocyte activation, recirculation and homing, and in hematopoiesis. CD44 is a receptor for LGALS9 - this interaction enhances SMAD3 binding to the FOXP3 promoter, up-regulating FOXP3 expression and increasing induced regulatory T (iTreg) cell stability and suppressive function. |
Alternative Name | HCAM; CD44 antigen; extracellular receptor III; ECMR III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; HUTCH I; HUTCH 1; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; PGP-1; PGP 1; PGP I |
UniProt | Q28284 |
Immunogen | YKIX 337.8.7 was prepared by immunizing rats canine thymocytes. |
Application Notes | YKIX 337.8.7 antibody can be used for IHC-Fr; YKIX 337.8.7 to distinguish CD4+ T-cell subsets. This antibody can additionally be used for FACS and IP. |
Antibody First Published | Cobbold et al. Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 1994 Mar;43(3):137-54. PMID:8091414 |
Note on publication | Describes the binding specificity and characterisation (by IF staining and FACS, and IP) of antibodies against canine equivalents of human CD antigens. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
