Key features and details | |
Cat. No. | MABL-995 |
Name | Anti-CD45RO mAbs |
Clone No. | AFD- UCH-L1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, WB, FC, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human CD45RO. |
Alternative Name | PTPRC; Protein tyrosine phosphatase; receptor type C; CD45 R; UCHL1; UCHL-1 |
UniProt | |
Immunogen | Cultured T cells from an IL-2-dependent T-cell line (CA1) prepared from human peripheral blood activated with influenza virus. |
Application Notes | PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. This antibody reacts with an epitope unique for CD45R0. It may identify abnormalities of functional T-cell subsets in immune disorders, be used in tumour diagnosis by FACS or immunohistology and has been very useful in studies of human T cell function and ontogeny. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
