Key features and details | |
Cat. No. | MABL-1049 |
Name | Anti-CD59 mAbs |
Clone No. | AFD- YTH 53.1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | Recognises CD59 18-20kD cell surface GPI linked glycoprotein broadly expressed by human leucocytes and erythrocytes. This protein is regulator of complement-mediated cell lysis by inhibiting the complement membrane attack complex formation of C8 and/or C9. |
Alternative Name | MAC-IP; CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; MAC-inhibitory protein; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; YTH53; YTH-53 |
UniProt | P13987 |
Immunogen | T lymphocytes in human PBMC. |
Application Notes | |
Antibody First Published | Davies A, Simmons DL, Hale G, Harrison RA, Tighe H, Lachmann PJ, Waldmann H. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med. 1989 Sep 1;170(3):637-54.PMID:2475570 |
Note on publication | Describes the preparation of antibody and characterisation of the specificities by immunofluorescence and flow cytometry and complement-mediated cell lysis assays. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
