Key features and details | |
Cat. No. | MABL-1051 |
Name | Anti-CD6 mAbs |
Clone No. | AFD- OX-126 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for the domain 2 of human CD6. Binding depends on a SNP ( R, amino acid 225). |
Alternative Name | TP120; OX126; MRC OX-126; MRC OX 126 |
UniProt | P30203 |
Immunogen | This antibody was raised by immunizing BALB/c mice with a fusion protein consisting of human CD6 domain 3 and rat CD4 domains 3 and 4 (CD6d3CD4d3 + 4) (corrected, see: (Hassan et al., 2019; pmid: 30890626)). |
Application Notes | This antibody is noncompetitive with OX125 and does not block CD6/CD166 interactions (Santos et al., 2019; pmid: 31162836). |
Antibody First Published | Hassan et al. CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76 MOLECULAR AND CELLULAR BIOLOGY, Sept. 2006, p.6727–6738 PMID:16914752 |
Note on publication | Describes the original use of this antibody to engage human CD6, blocking the CD6/CD166 interaction. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
