Anti-Complement Factor D mAbs

Cat. No.

MABL-1255

Name

Anti-Complement Factor D mAbs

Clone No.

AFD- D10/4

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, ELISA

Species Reactivity

Human

Basic Information

Specificity

D10/4 antibody recognizes human complement   factor D. Complement factor D is a serine protease of the alternative pathway of complement activation.Factor D cleaves factor B bound to C3b, generating   the alternative pathway C3 convertase C3bBb and releasing the Ba fragment.

Alternative Name

Adipsin; C3 convertase activator; Properdin   factor D; CFD; factor D

UniProt

P00746

Immunogen

This antibody was raised by immunizing BALB/c   mice with the purified complement factor D and by the subsequent generation   of hybridomas.

Application Notes

D10/4 antibody can be used for the   identification of the complement factor D from human serum and plasma. For   instance, this antibody was utilized in the quantitation of the factor D   levels in blood of patients with renal failure via a senstive ELISA procedure   (Oppermann et al., 1991).

Antibody First Published

Oppermann et al. Quantitation of components   of the alternative pathway of complement (APC) by enzyme-linked immunosorbent   assays. J Immunol Methods. 1990 Oct 19;133(2)：181-90. PMID：2146321

Note on publication

This article describes the generation and   characterization of the D10/4 antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.