Key features and details | |
Cat. No. | MABL-1336 |
Name | Anti-Cytokeratin 18 mAbs |
Clone No. | AFD- RCK106 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, FC, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody reacts exclusively with Cytokeratin 18 in glandular epithelial cells of the digestive, respiratory, and urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them. |
Alternative Name | K18; CK-18; Keratin K18; Keratin type I cytoskeletal 18; Cell proliferation- inducing gene 46 protein; Cytokeratin-18; Keratin-18 |
UniProt | P05783 |
Immunogen | The original antibody was generated by immunizing a mouse with cytokeratins from the Human bladder carcinoma cell line T24. |
Application Notes | The antibody detected Cytokeratin 18 by western blot analysis. The antibody reacted with endocervical columnar cells, cervical immature squamous metaplasia and CINIII by immunohistochemistry (Smedts et al., 1990; PMID： 1690513). The antibody stained transitional cell carcinomas of the urinary tract of different grade and stage (Schaafsma et al., 1990; PMID： 1689541). |
Antibody First Published | Ramaekers et al. Tissue distribution of keratin 7 as monitored by a monoclonal antibody Exp Cell Res. 1987 May;170(1)：235-49. PMID：2436934 |
Note on publication | The original paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
