Key features and details | |
Cat. No. | MABL-1358 |
Name | Anti-D3H44 mAbs |
Clone No. | AFD- 6A6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | |
Alternative Name | AbD3H44 idiotype; humanized anti-TF antibody D3H44 |
UniProt | |
Immunogen | Humanised monoclonal antibody D3H44. |
Application Notes | The antibody binds specifically to the humanised anti-tissue factor antibody D3H44 and is able to neutralise the anticoagulant activity of D3H44. The anti-idiotypic 6A6 antibody acts by competing with the TF binding site, and can therefore be used in anticoagulation therapy with D3H44 antibody to control bleeding. |
Antibody First Published | Eigenbrot et al. Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. J Mol Biol. 2003 Aug 8;331(2):433-46. PMID:12888350 |
Note on publication | Describes the structural characterisation of the monoclonal antibody 6A6, which is able to mimic tissue factor and thereby compete with it for binding to the neutralising humanised antibody D3H44. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
