Key features and details | |
Cat. No. | MABL-1410 |
Name | Anti-DM1 mAbs |
Clone No. | AFD- 06CT8.1.1.1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | This antibody binds maytansine (DM1), a thiol-containing maytansinoid which is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. The potent cell killing ability of maytansine can be used in a targeted delivery approach, such as an antibody-drug conjugate (ADC), for the selective delivery of the drug and destruction of cancer cells. ADCs with this design include trastuzumab emtansine, lorvotuzumab mertansine, and cantuzumab mertansine. |
Alternative Name | Mertansine; Maytansinoid |
UniProt | |
Immunogen | The original antibody was generated by immunizing BALB/c mice with DM1-cysteine-KLH conjugate. |
Application Notes | The binding reactivity of this antibody towards BSA-DM1 was determined using ELISA. This antibody is recommended for detection of antibody-drug conjugates containing DM1 (CN114276448). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
