Key features and details | |
Cat. No. | MABL-1435 |
Name | Anti-DR5 mAbs |
Clone No. | AFD- Fab-BDF1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody binds to human DR5 with nanomolar affinity.The original format of this antibody has an IC50-value of 2 nM |
Alternative Name | TRAIL receptor 2; Proapoptotic Death Receptor DR5; Death Receptor 5; TRAIL receptor 2; TRAILR2; Tumor Necrosis Factor Receptor Superfamily Meber 10B; TNFRSF10B |
UniProt | Q9BY82 |
Immunogen | Human immobilized DR5. |
Application Notes | The antibody binds to human DR5, a receptor that can be activated by tumor necrosis factor-related ligands and transduces apotposis signals. The antibody occludes the smaller of the two Apo2L/TRAIL binding sites on DR5 |
Antibody First Published | Li et al. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. Journal of Molecular Biology 2006; 361(3):522-36 PMID:16859704 |
Note on publication | Describes the use of phage display to generate a synthetic antibody against human proapoptotic death receptor DR5 and subsequent crystallography. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
