Key features and details | |
Cat. No. | MABL-1519 |
Name | Anti-Erythropoietin receptor mAbs |
Clone No. | AFD- Ab198 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, SFA, SPR |
Species Reactivity | Human |
Basic Information | |
Specificity | |
Alternative Name | EPO-R |
UniProt | P19235 |
Immunogen | Ab198 was generated by immunising XenoMouse mice (humanised immune system) with soluble human EpoR. |
Application Notes | RIA showed that Ab198 competes with EPO for binding to EPO-R. SPR determined the Kd of Ab198 binding to EPO-R as 13.9 nM. In an EPO dependent human cell proliferation assay Ab198 stimulated proliferation of the F36E cell line. Ab198 also induced proliferation of human erythroid producing cells derived from progenitor cells in a dose-dependent manner. In a cynomolgus bone marrow CFUe assay Ab198 induced the formation of CFU-E colonies. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
