Anti-Folate receptor beta mAbs

Cat. No.

MABL-1620

Name

Anti-Folate receptor beta mAbs

Clone No.

AFD- CL10

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, IHC

Species Reactivity

Mouse

Basic Information

Specificity

Alternative Name

FRβ; Folate receptor 2; Folate-binding   protein 2.

UniProt

Q05685

Immunogen

FRβ-transfected RBL2H3 cells.

Application Notes

The antibody binds specifically to FRβ, a member   of the folate receptor family. The receptor binds with high affinity to folic   acid and folic acid derivatives, and transports 5- methyltetrahydrofolate   into the cell. The receptor is expressed on the surface of tumour associated   macrophages (TAMs) that promote growth and metastasis of tumours such as   gliomas and colon, breast and lung carcinomas. Research has shown FRβ is only   expressed on activated macrophages, and thereby a monoclonal antibody that   targets the receptor can be useful in the diagnosis of the cancer.   Furthermore, the antibody may be conjugated with a toxin, delivering the drug   only to TAMs and not to healthy macrophages.

Antibody First   Published

Nagai T, Tanaka M, Tsuneyoshi Y, Xu B,   Michie SA, Hasui K, Hirano H, Arita K, Matsuyama T. Targeting   tumor-associated macrophages in an experimental glioma model with a   recombinant immunotoxin to folate receptor beta. Cancer Immunol Immunother.   2009 Oct;58(10):1577-86. PMID:19238383

Note on publication

Describes the expression of folate receptor   beta on macrophages in glioblastomas, and the production of an antibody   against the receptor which can reduce tumour growth.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.