Key features and details | |
Cat. No. | MABL-1634 |
Name | Anti-FVIIa DVQ mAbs |
Clone No. | AFD- mAb4F5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallization, SPR |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for FVIIa. In particular, the epitope interacts with the periphery of the hydrophobic pocket. |
Alternative Name | SPCA; Eptacog alfa; Proconvertin; Coagulation factor VII; EC：3.4.21.21; Blood coagulation factor VIIa; Serum prothrombin conversion accelerator |
UniProt | P08709 |
Immunogen | The original antibody was generated by immunizing mice with FVIIaDVQ. |
Application Notes | The binding affinity of original format of the antibody to FVIIaDVQ was measured by surface plasmon resonance (Kd= 32 pM). The crystal structure of the Fab fragment of the antibody was determined (Jiang et al., 2019; PMID： 31294329). |
Antibody First Published | Jiang et al. Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism Res Pract Thromb Haemost. 2019 Jul; 3(3)： 412–419. Published online 2019 Jun 20. doi: 10.1002/rth2.12211 PMID: 31294329 |
Note on publication | The original paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
