Anti-gH mAbs

Cat. No.

MABL-1687

Name

Anti-gH mAbs

Clone No.

AFD- YC15

From

Recombinant Antibody

Isotype

Engineer antibody

Application

NTRL, FC

Species Reactivity

KSHV

Basic Information

Specificity

This mAb binds KSHV glycoprotein H. KSHV is  a human herpesvirus which is associated with Kaposi's sarcoma, however is   also implicated in 2 distinct B cell lymphoproliferative disorders.

Alternative Name

KSHV gH; Glycoprotein H; Kaposi's   sarcoma-associated herpesvirus glycoprotein H; KSHV glycoprotein H; KSHV   envelope glycoprotein H; Envelope glycoprotein H

UniProt

F5HAK9

Immunogen

Antibodies were produced from a murine hybridoma.

Application Notes

YC15 was reformatted as a scFv fragment and   combined with Pseudomonas aeruginosa exotoxin A to create an immunotoxin   against KSHV-infected cells (Cai & Berger, 2011). YC15 was shown to bind   cells expressing gH on the surface using flow cytometry, where binding was   sufficient to neutralise gH activity and also induce a cytotoxic effect.

Antibody First   Published

Cai & Berger. An immunotoxin targeting   the gH glycoprotein of KSHV for selective killing of cells in the lytic phase   of infection. Antiviral Res. 2011 Jun;90(3)：143-50. PMID：21440007

Note on publication

Describes the design, expression and   characterisation of an immunotoxin against KSHV-infected cells. YC15 was used   within this study, however the details of its generation are unpublished.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.