Key features and details | |
Cat. No. | MABL-1700 |
Name | Anti-GITR mAbs |
Clone No. | AFD- YGITR765 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody binds murine GITR. |
Alternative Name | CD357; Tumor necrosis factor receptor superfamily member 18; TNFRSF18; AITR; GITR-D; activation-inducible TNFR family receptor; AITR; glucocorticoid-induced tumor necrosis factor receptor |
UniProt | |
Immunogen | nB2/6TG cells transfected with mouse GITR injected into DA rats. |
Application Notes | A chimeric version of this antibody featuring a human IgG1 Fc-portion engineered to lack the N-linked glycosylation site at amino acid 297 was shown to enhance humoral immune responses by blocking GITR signallin (Ponte 2010). |
Antibody First Published | Cobbold et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol. 2004 May 15;172(10)：6003-10. PMID：15128783 |
Note on publication | Describes the use of this antibody in flow cytometry. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
