Key features and details | |
Cat. No. | MABL-1737 |
Name | Anti-gp41 mAbs |
Clone No. | AFD- SL5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | neutralization, ELISA |
Species Reactivity | Simian immunodeficiency virus |
Basic Information | |
Specificity | The antibody is specific for gp41. |
Alternative Name | Envelope glycoprotein gp160; Transmembrane protein gp41; Glycoprotein 41 |
UniProt | B0LB91 |
Immunogen | A single chain fragment variable (scFv) phage display library was constructed from a simian immunodeficiency virus (SIV)-infected rhesus macaque. The original antibody was isolated by panning onto oligomeric (gp140) and monomeric (gp120) forms of SIV Env glycoprotein. |
Application Notes | The specificity of the original format of the antibody was confirmed by ELISA analysis. The scFv format was able to neutralize SIVmac316. The original antibody was converted in the scFv-Fc format and its specificity validated by WB (Ita et al., 2017; PMID: 28075174). |
Antibody First Published | Ita et al. Analysis of SIVmac Envelope-Specific Antibodies Selected Through Phage Display. AIDS Res Hum Retroviruses. 2017 Aug;33(8): 869-879. PMID：2807517.4 |
Note on publication | The original paper describes the generation and characterization of the antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
