Key features and details | |
Cat. No. | MABL-1750 |
Name | Anti-GXM mAbs |
Clone No. | AFD- 2H1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | therapeutic, ELISA |
Species Reactivity | Cryptococcus neoformans |
Basic Information | |
Specificity | This antibody is specific for GXM from C.neoformans. GXM is a polysacharide experssed on the surface of c.neoformans. |
Alternative Name | Glucuronoxylomannan; Cryptococcus neoformans capsular polysaccharide; CNPS |
UniProt | |
Immunogen | The original mouse version of this antibody was raised by infecting balb/c mice with C. neoformans and then immunizing them with glucuronoxylomannan-tetanus toxoid conjugate (GXM-TT). |
Application Notes | To characterize the mouse version of this antibody an ELISA was performed on native and de-O-acetylated serotype A GMX using the mouse version of this antibody (Casadevall et al, 1992; pmid:1583327). In research on the efficacy of the mouse version of this antibody against diverse strains of Cryptococcus neoformans. This antibody showed the ability to reduce the amount of yeast cells present in the organs of mice (Mukherjee et al, 1995; pmid:7642262). |
Antibody First Published | Casadevall et al. Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection J Infect Dis. 1992 Jun;165(6):1086-93. PMID:1583327 |
Note on publication | The antibody responses of BALB/c mice to serotype A Cryptococcus neoformans capsular polysaccharide (CNPS) were compared after cryptococcal infection and immunization with a serotype A glucuronoxylomannan-tetanus toxoid conjugate. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
