Key features and details | |
Cat. No. | MABL-1846 |
Name | Anti-HLA class I mAbs |
Clone No. | AFD- F17B1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FACS, in vivo, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for HLA class I. The antibody binds to the following subclasses: A2, A3, A11, A23, A24, A25, A26, A29, A30, A31, A32, A33, A34, A68. |
Alternative Name | |
UniProt | |
Immunogen | The original antibody was generated by immunizing male MRL/lpr mice with an an emulsion containing complete adjuvant H37Ra and purified sHLA-A-flag protein. |
Application Notes | The original antibody showed strong cell death-inducing activity by FACS analysis. The antibody was used for detection of beads coated HLA class I antigen by flow cytometry. The human chimeric and the humanized version of the antibody was constructed. The human chimeric antibody was administered into a mouse model for human myeloma. The result showed that the antibody can significantly prolong the survival period of the mouse model for human myeloma. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
