Key features and details | |
Cat. No. | MABL-1922 |
Name | Anti-ICOS mAbs |
Clone No. | AFD- 7E.17G9 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This anitbody binds to mouse ICOS (CD278). |
Alternative Name | CD278; AILIM; CVID1; inducible T-cell co-stimulator; inducible T-cell costimulator; 7E.17G9.G1.G7 |
UniProt | |
Immunogen | Rats were immunized i.m. three times with 500 mg murine ICOS cDNA in the pAXEF mammalian expression vector and boosted twice with 200 mg murine ICOS hexahistidine fusion protein. |
Application Notes | This antibody can be used to detect mouse ICOS by flow-cytometry. Maazi et al (2015, PMID: 25769613) showed that 7E.17G9 can inhibit ICOS interaction with its ligand ICOSL. |
Antibody First Published | McAdam et al. Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells J Immunol. 2000 Nov 1;165(9):5035-40. PMID:11046032 |
Note on publication | Describes the generation of this antibody and its use in detecting ICOS by flow- cytometry. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
