Anti-IL-12/IL-23p40 mAbs

Cat. No.

MABL-2023

Name

Anti-IL-12/IL-23p40 mAbs

Clone No.

AFD- CNTO 1275   (Ustekinumab)

From

Recombinant Antibody

Isotype

Engineer antibody

Application

in vivo, therapeutic, Block

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for the p40   subunit of human IL-12/23.

Alternative Name

p40; IL-12; IL-12p40; IL-12B; IL-23;   IL-23p40

UniProt

Immunogen

The original antibody was produced by   immunizing human immunoglobulin transgenic mice ((CBA/J×C57/BL6/J) F2 hybrid)   with human recombinant IL-12.

Application Notes

This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279)   (Sands et al., 2019; PMID: 31553833).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.