Anti-IL-13 mAbs

Cat. No.

MABL-2029

Name

Anti-IL-13 mAbs

Clone No.

AFD- DOM10-53-616

From

Recombinant Antibody

Isotype

Engineer antibody

Application

neutralize, ELISA

Species Reactivity

Human, Rhesus Monkey, Cynomolgus Monkey

Basic Information

Specificity

This antibody binds human interleukin-13. It   is also reported to cross react with cynomolgus monkey and rhesus monkey IL13. Interleukin-13 is a cytokine secreted by T helper type 2 (Th2) cells,   CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and   nuocytes. It inhibits the production of inflammatory cytokines (IL-1, IL-6,   TNF, IL-8) by LPS-stimulated monocytes. It synergizes with IL2 in regulating   interferon-gamma synthesis. It is a mediator of allergic inflammation and   different diseases including asthma.

Alternative Name

IL13; NC30; Interleukin-13; DOM10-53-546;   DOM10-53-386

UniProt

P35225

Immunogen

The original antibody DOM10-53-546 was isolated   from in-line fusion libraries selected against human IL-13. This antibody   (DOM10-53-616) was generated by replacing the CDR2 of DOM10-53- 546 with that   of DOM10-53-386.

Application Notes

The binding characterization of this   antibody to human, cynomolgus monkey and rhesus monkey IL-13 was done using   ELISA. The binding affinity of the original single chain VHH antibody was   assessed using BIAcore analysis. It was reported that the original VHH   antibody bound human and cynomolgus monkey IL13 with a binding affinity of   130 pM and 3.2 pM respectively. This antibody shows neutralizing potency for   human, cynomolgus monkey and rhesus IL-13 (US20110236380).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.