Key features and details | |
Cat. No. | MABL-2146 |
Name | Anti-Insulin receptor alpha mAbs |
Clone No. | AFD- Fab 83-7 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallization |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognizes an epitope within the cysteine rich region (amino acids 140-301) of the extracellular domain of the human insulin receptor alpha. |
Alternative Name | CD220 |
UniProt | P06213 |
Immunogen | This antibody was raised by immunizing mice with IM-9 lymphocytes followed by purified insulin receptor. |
Application Notes | This antibody forms a stable complex with the L1-CR fragment of the human insulin receptor alpha-subunit. Consequently, this antibody can be used to facilitate the crystallization of the complex, and the establishment of its structure (McKern et al, 2006). |
Antibody First Published | McKern et al. Structure of the insulin receptor ectodomain reveals a folded- over conformation Nature, 2006, Vol.443(7108), p.218 PMID:16957736 |
Note on publication | Describes the original generation of Fab fragments for Mab 83-7, and their subsequent use in the crystallization of insulin receptor alpha. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
