Anti-JBP1 mAbs

Cat. No.

MABL-2177

Name

Anti-JBP1 mAbs

Clone No.

AFD- Nb6

From

Recombinant Antibody

Isotype

Engineer antibody

Application

crystallization, SPR

Species Reactivity

Leishmania tarentolae

Basic Information

Specificity

This antibody is specific for J-base binding   protein 1 (JBP1), a protein that contributes to the biosynthesis and   maintenance of base J (β-d-glucosylhydroxymethyluracil), a modification of   thymidine confined to some protozoa.

Alternative Name

J-binding protein 1; J-base binding protein 1; Thymine dioxygenase JBP1

UniProt

Q9U6M1

Immunogen

Application Notes

Surface plasmon resonance screening identified this antibody as a strong binder,recognizing JBP1 with a 1:1 stoichiometry and high affinity (Kd = 30 nM) (van Beusekom et al., 2018; PMID: 30387773).

Antibody First   Published

van Beusekom et al. Characterization and   structure determination of a llama-derived nanobody targeting the J-base   binding protein 1 Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt   11):690-695. doi: 10.1107/S2053230X18010282 PMID:30387773

Note on publication

The original publication describes the   characterization and structure determination of a llama-derived nanobody that   targets the J-base binding protein 1 (JBP1), which is involved in the   biosynthesis and maintenance of base J, a thymidine modification found in   certain protozoa.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.