Key features and details | |
Cat. No. | MABL-2218 |
Name | Anti-LAG-3 mAbs |
Clone No. | AFD- Ab8438 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, SPR |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for human LAG-3. The antibody cross-reacts with cynomolgus LAG-3. The antibody does not cross react with murine LAG-3. |
Alternative Name | CD223; LAG3; FDC; Lymphocyte activation gene 3 protein |
UniProt | P18628 |
Immunogen | |
Application Notes | The antibody is a humanized version of the mouse antibody mab84c. The humanized antibody could bind to hLAG-3+ cells, with an EC50 value that does not exceed 1.5nM. The humanized antibody prevented the binding activity of human LAG-3 and Daudi cells. The binding affinity of the humanized antibody was measured by surface plasmon resonance (Kd= 0.71 nM). The antibody was employed to design bispecific antibodies against LAG-3 and PD-L1, which antibody retained the binding activity to dual-target LAG3 and PD-1. Further, both the combination of the antibody and PD-1 antibody and the bispecific LAG-3 and PD-L1 antibody showed a good tumour inhibition effect in in vivo application (CN111848794). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
