Key features and details | |
Cat. No. | MABL-2275 |
Name | Anti-Lox-1 mAbs |
Clone No. | AFD- AbAb01LOX1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds oxidized low density lipoprotein (ox-LDL), which is a receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. |
Alternative Name | LOX1; hLOX-1; OLR1; CLEC8A; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; Lectin- like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; Oxidized low-density lipoprotein receptor 1 soluble form |
UniProt | P78380 |
Immunogen | The original antibody was isolated from a human scFv phage display library by panning against human Lox-1. |
Application Notes | This antibody can be used for the detection of Lox-1, which is a marker for early diagnosis of atherosclerosis. The binding characterization of this antibody was done using ELISA. The binding affinity of this antibody for human Lox-1 was determined using Bio-layer Interferometry (BLI) and it was reported that the binding affinity of this scFv antibody was Kd= 6.69 nM (CN107216390). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
