Key features and details | |
Cat. No. | MABL-2305 |
Name | Anti-M-CSF mAbs |
Clone No. | AFD- 5H4 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | neutralizing, SPR |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for M-CSF. The antibody binds to a linear epitope represented by ITFEFVDQE, amino acids 65-73 of M-CSF. |
Alternative Name | CSF-1; MCSF; PG-M-CSF; Lanimostim; Macrophage colony-stimulating factor; Macrophage colony-stimulating factor 1; Proteoglycan macrophage colony-stimulating factor |
UniProt | P09603 |
Immunogen | |
Application Notes | The binding properties of the original format of the antibody were analyzed using SPR analyses (Kd = 3 nM). The antibody could neutralize human M-CSF activity, as measured by a proliferation assay with M-NFS-60 cell line. Further, the Fab fragment of the antibody was able to neutralize human M- CSF activity, but with less potency. The humanized variant of the antibody was constructed (EP1913028B1). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
