Key features and details | |
Cat. No. | MABL-2342 |
Name | Anti-Membrane type 1 metalloprotease mAbs |
Clone No. | AFD- LEM-2/15 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to residues 218-233 of the V-B loop of MT1-MMP with a Kd of 2.32E10-9M. |
Alternative Name | MT1-MMP |
UniProt | |
Immunogen | The cyclic peptide possessing the sequence of residues 218-233 of the V-B-loop of MT1-MMP. |
Application Notes | This antibody binds to residues 218-233 of the V-B loop of MT1-MMP which is a mediator of cell migration and is frequently involved in malignancy of tumours by promoting metastasis.The antibody acts as a non-competitive inhibitor of the receptor. |
Antibody First Published | Udi et al. 2015 Inhibition mechanisms of membrane metalloprotease by an exosite swiveling conformational antibody. Structure 2015; 23: 104-115 PMID:25482542 |
Note on publication | Describes the crystal structures of the LEM-2/15 bound to MT1-MMP. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
