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Anti-NKG2D mAbs

简要描述:

This antibody recognizes human, cynomolgous monkey and rhesus monkey NKG2D, but does not cross react with mouse rat, dog or pig NKG2D. Natural killer (NK) cells serve as key innate effectors and their activity has been considered a prognostic biomarker in diverse human diseases. NKG2d functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity.

产品参数:

Cat. No.:MABL-2480

Species:Engineer

Species Reactivity:cynomolgous monkey, Human, Rhesus Monkey

Type:Recombinate

Application:ELISA, FC

详细介绍

Key features and   details


Cat. No.

MABL-2480

Name

Anti-NKG2D mAbs

Clone No.

AFD- 16F16

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ELISA, FC

Species Reactivity

cynomolgous monkey, Human, Rhesus Monkey

Basic Information


Specificity

This antibody recognizes human, cynomolgous   monkey and rhesus monkey NKG2D, but does not cross react with mouse rat, dog   or pig NKG2D. Natural killer (NK) cells serve as key innate effectors and   their activity has been considered a prognostic biomarker in diverse human   diseases. NKG2d functions as an activating and costimulatory receptor   involved in immunosurveillance upon binding to various cellular   stress-inducible ligands displayed at the surface of autologous tumor cells   and virus-infected cells. It provides both stimulatory and costimulatory   innate immune responses on activated killer (NK) cells, leading to cytotoxic   activity. 

Alternative Name

KLRK1; CD314; NKG2-D type II integral   membrane protein; NK cell receptor D; Killer cell lectin-like receptor   subfamily K member 1; NKG2-D-activating NK receptor; KYK2; KYK- 2.0

UniProt

P26718

Immunogen

The original antibody was generated by   immunizing KM Mouse™ strain of transgenic mice that express human antibody genes with alternating intraperitoneal injection of NKG2D-transfected BAF   cells and NKG2D-transfected CHO cells, or primary human NK cells. The second   round of immunizations were done using NKG2D-hFc as an immunogen.

Application Notes

The primary screening of this antibody for   binding NKG2D was done using ELISA. This antibody was successful in staining and identification NKG2D expressed on PBMCs isolated from human, cynomolgous   monkey and rhesus monkey in a flow cytometric assay. The original human IgG4   version of this antibody bouund NKG2D with an affinity of 0.172nM. This   antibody was also capable of blocking binding of NKG2D to MICA and preventing   killing of MICA-bearing cells by NKL cells in a dose-dependent fashion.This   anitbody also inhibited killing of both MICA- and ULBP-bearing BaF/3 target   cells by NK-92 cells in a dose dependent manner (US7879985).

Antibody First   Published


Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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